Effects of E-0747 on action potential duration and automaticity in Purkinje fibers, right ventricular muscles and sinus nodes of swine hearts

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Depolarization and action potential duration in cardiac Purkinje fibers.

The effect of depolarization on the duration of the action potential was studied in short cardiac Purkinje fibers. Membrane potential was altered by overdriving pacemaker fibers showing spontaneous diastolic depolarization (dog), by injecting constantcurrent pulses through an intracellular microelectrode (sheep), or by voltage clamping (dog). Test action potentials were elicited at the end of 5...

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Depolarization and Action Potential Duration in Cardiac Purkinje Fibers

The effect of depolarization on the duration of the action potential was studied in short cardiac Purkinje fibers. Membrane potential was altered by overdriving pacemaker fibers showing spontaneous diastolic depolarization (dog), by injecting constantcurrent pulses through an intracellular microelectrode (sheep), or by voltage clamping (dog). Test action potentials were elicited at the end of 5...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1988

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)57479-0